Charge Heterogeneity Analysis of Intact Monoclonal Antibodies
using CESI-MS



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Duration: Approximately 20 minutes

EsmeCandish.pngEsme Candish is an Application Scientist with SCIEX. Her current work focuses on applying CE and CESI-MS for the analysis of proteins and post-translational modifications.

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Integrating CE and electrospray ionization (ESI) into one dynamic process, within the same device (CESI), simplifies coupling CE with MS. See how CESI-MS is used to characterize mAbs at the intact level.

CESI-MS can be employed to characterize differences in the charge and glycosylation profiles of mAbs from different manufacturers.

By viewing this presentation you will be shown...

  • the value of CESI-MS to the characterization of mAbs
  • how the technique can characterize differences in charge and glycosylation profiles

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