Developing, Testing and Troubleshooting Chromatography Method Transfer

Developing, Testing and Troubleshooting Chromatography Method Transfer

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The transfer of chromatographic methods occurs at many stages in the development and production of a product. In its simplest form, the method is moved from one laboratory to another within the same organization, holding all instrumental and chemical parameters constant. More commonly, however, it is necessary to accommodate changes in available instrumentation. We will describe the steps in moving to new instrumentation as well as the role of information rich detectors in confirming a successful transfer that preserves analytical quality and accuracy. The more challenging process of migrating a method to more modern instruments and column chemistry will also be considered.

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