How to Achieve Accurate Water Content Results with Karl Fischer Titration
BettinaStraubJubbBettina Straub-Jubb, Product Manager & Lead Expert for Titration at the life science business of Merck KGaA, Darmstadt, Germany
Transparent and accurate analysis results are an important prerequisite for meeting your customers' quality expectations on products, raw materials and processes. A central analytical parameter is the water content. Water can influence stability, durability, permeability, or consistency of materials, or the energy consumption, yield, and safety in production processes. Therefore, exact water determination is necessary in a wide variety of industries. The Karl Fischer titration method is still the most used, fastest, and most precise method for measuring water content to get accurate, transparent, and comparable results. By watching this presentation, you will learn:

  • The difference between Volumetry and Coulometry
  • How to improve your Karl Fischer titration process
  • The key quality assurance requirement
  • How to perform an accurate titer determination
  • Tips to avoid failures

Duration: Approximately 60 mins

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The Karl Fischer Oven Method – Step by Step
MichaelMargrethMichael Margreth, Application Specialist - Karl Fischer Titration and Water Determination, Metrohm
Karl Fischer (KF) titration is a standard method for the water content determination in all types of substances. However, for various reasons, some substances are not suitable for a direct Karl Fischer titration. These reasons include that they undergo side reaction with KF reagents; they contaminate the titration cell and/or the electrodes; the substances are poorly soluble in alcohol; they release their water only slowly; or the water is released at high temperatures only. These problems can be avoided by using the oven method. This makes the KF oven method the perfect solution for the analysis of difficult samples. By watching this presentation, you will learn:

  • The principle of the oven method
  • How to properly prepare your titration system with an oven
  • How to prepare your sample
  • How to select the optimal oven temperature

After viewing this webinar, you will know how to perform accurate sample measurements using the oven method.

Importance of CRM-grade Karl Fischer Standards for Accurate KF Titration
ShaillyKrishnaRajusthShailly Krishna-Rajusth, Product Manager for Physical & Chemical Property Standards at the life science business of Merck KGaA, Darmstadt, Germany
Karl Fischer (KF) titration is one of the most rapid and accurate methods to determine water content in various samples. For accurate KF titration, high quality Certified Reference Materials (CRMs) are essential. In this webinar, we will present key reference material terms, different quality grades of reference materials, and an overview of our portfolio of high-quality CRM-grade KF Standards. By watching this presentation, you will learn:

  • Key terms: Metrological Traceability, Quality Grades, 17025 & 17034 Accreditation
  • The importance of using the right quality grade of KF standards for your application
  • An overview of our unmatched portfolio of KF standards 

Duration: Approximately 60 mins

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Direct Karl-Fischer Titration or Gas Phase Extraction – A Closer Look
ThomasHitzThomas Hitz, PhD Application Development, Automated Karl-Fischer Titration, Mettler Toledo
In this presentation we will compare the direct addition with the gas phase extraction method. For this purpose, various sample types were analyzed by either direct addition, gas phase extraction, or both. Among the tested sample types are powders, oils, and cannabis flower. We will discuss the challenges that such samples represent and highlight the analytical measures that will ensure to obtain the best results possible. By watching this presentation, you will learn about:

  • Direct titration vs. gas phase extraction method
  • Advantages of the Karl Fischer oven method (gas phase extraction)
  • Application examples: oils / cannabis flower

Validation of Parameters for Karl Fischer Titration
AngelaSchwehnAngela Schwehn, Laboratory Scientist in the R&D Department of the life science business of Merck KGaA, Darmstadt, Germany
Validation of parameters for a Karl Fischer titration method is an essential prerequisite for laboratories. Performance characteristics of the procedure need to meet the requirements for its intended purpose. You will learn typical analytical performance parameters that should be considered in the validation of the Karl Fischer titration procedures. The objective of this session is to present the requirements for a titration process. By watching this presentation, you will learn about:

  • General aspects of validation
  • Required validation parameters
  • How to verify the suitability and accuracy of a titration method
  • An overview of the parameters described in ICH (International Council for Harmonization) guidance Q2(R1) and USP general chapter <1225> (selectivity, linearity, accuracy & reproducibility)

Duration: Approximately 45 mins

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Roundtable Expert Discussion
Together with our partners Metrohm and Mettler Toledo, Merck KGaA, Darmstadt, Germany discuss the trends and key aspects of Karl Fischer titration. We cover some questions asked during the other three parts, as well as answering new questions during the roundtable discussion.  
This event is moderated by Ernie Hillier, Independent Pharmaceutical Consultant, EJH Consulting and participants are Bettina Straub-Jubb, Dr. Shailly Krishna Rajusth, and Angela Schwehn from Merck Life Science KGaA, Darmstadt, Germany, Thomas Hitz from Mettler-Toledo, and Michael Margreth from Metrohm AG. 

BettinaStraubJubb   ShaillyKrishnaRajusth   AngelaSchwehn   ThomasHitz   MichaelMargreth

Duration: Approximately 50 mins

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Bonus Content: Access the FAQS 

A PDF copy of the frequently asked questions that emerged during the 'Karl Fischer Titration Week' is also available to download. This download will be included with all on-demand registrations.







The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada.

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