Analysis of Lipid Nanoparticle Composition

Separation Science, in collaboration with Agilent, offers an application note covering a liquid chromatographic method development for the analysis of the lipid components of patisaran.

Application Overview

This application note describes the analysis of the lipid components of patisaran (trade name Onpattro) using an Agilent 1260 Infinity II Prime Bio LC system and evaporative light scattering detection (ELSD). Optimal separation of the four lipid nanoparticle components was achieved with excellent peak shapes, precision, and sensitivity.

From this application note, you will learn about:

  • Composition and structure of lipid nanoparticles (LNPs)
  • How to achieve best LC separation for the LNP components
  • How to use the ELSD for universal detection

Listen to application note author Dr Sonja Schneider discuss the key elements of this work - simply click on the image below:



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Author & Presenter:

SonjaSchneider_200Dr Sonja Schneider
Application Development Manager,
Agilent Technologies