Elevate the Performance of your GC (and MS): Strategies to Improve Sensitivity and Reliability with Complex Matrix Samples


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Duration: Approximately 60 minutes


Vanessa_Abercrombie_80Vanessa Abercrombie 
(Gas Chromatography Applications Chemist, Agilent Technologies, USA)

Vanessa Abercrombie is GC Applications Chemist at Agilent Technologies in Folsom, California, USA. Vanessa has a broad background in GC and GC/MS, including experience as an instrument chemist at Bode Technology in Virginia working under contract to the FBI’s Laboratory Division. Prior to that, Vanessa worked for ETS Labs in St. Helena, California as an Analytical Chemist where she researched and developed quantitative separations by GC/MS and UHPLC for beer, wine and spirits. She holds a Masters of Forensic Science from The George Washington University and a Bachelor of Arts in Chemistry from Sonoma State University. 


Limian_ZhaoLimian Zhao
(Sample Preparation Applications Scientist, Agilent Technologies, USA)

Ms. Limian Zhao is a senior application scientist in Agilent Technologies Inc. She has been working with Agilent since 2008, involved in many product research, development and application projects, including LC, GC and sample preparation consumable products. She has over 15 years’ practical experiences in food, clinical and environmental testing industries, especially with knowledge and hands-on experience in many sample preparation techniques as well as analytical instrumentations. She understands the challenges that customers face with sample preparation issues across many markets and application areas. Limian has M.Sc degrees in the fields of Analytical Chemistry and Food Chemistry. 


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In an ideal world, samples would always be clean, easy to inject and analyse and your GC and MS systems would maintain their sensitivity indefinitely. The reality is that most samples cannot be directly injected onto the GC and MS detection system, and sample preparation is often needed to achieve the desired sensitivity. Sometimes simple fixes, such as choosing the right liner, switching to a high efficiency column, or utilizing “jet clean” on the MS can make a big difference on the sensitivity of the analysis.  But often, sample preparation is the critical step needed to get samples ready for GC or GC/MS(-MS) analysis. Appropriate sample preparation techniques not only make samples amenable for GC injection at concentrations suitable for detection, but also remove and prevent unwanted matrix components from accumulating and deteriorating on the GC and GC/MS flow path. We will discuss useful strategies, including choosing the right GC column and supplies, as well as what level of sample preparation, and maintenance is required for method reliability and analytical data quality, using challenging representative applications such as PAHs in salmon oil and pesticides in fatty matrices.

What does it cover?

GC high efficiency columns and liner selection, and sample preparation methods/techniques to improve the sensitivity and reliability of your GC and GC/MS analysis.

By viewing this presentation you will learn:

  • some of the strategies you can employ when working with complex matrix samples
  • how to reduce instrument down time due to needed maintenance such as source cleaning
  • how sample preparation can benefit your GC and GC/MS(-MS) analysis.

Why should you view it?

To gain better understanding of:

  • strategies that can be implemented when working with complex matrix samples and still maintain the sensitivity and reliability of your GC and GC/MS(-MS) system.
  • how gas quality, thermal stability, and column bleed can affect your chromatography.
  • sample preparation techniques/methods and their importance to improve method sensitivity and reliability.

This presentation is suitable for...

Laboratory technicians, researchers, and scientists wishing to learn more about how to analyse heavy matrix samples and learn about sample preparation.

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