High pH Stability of Columns Packed with Hybrid Fully Porous Particles and Hybrid-Coated Solid-Core Particles

Developing, Testing and Troubleshooting Chromatography Method Transfer

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High pH Stability of Columns Packed with Hybrid Fully Porous Particles and Hybrid-Coated Solid-Core Particles
MCJung_Web.pngpresented by Moon Chul Jung

Advancements in solid-core particle technology have enabled improved chromatographic efficiency and faster analyses. Because the majority of currently available solid-core particles are made of silica, these benefits may not be realized for applications that require high pH mobile phases. We have recently investigated the application of organic/inorganic hybrid coatings onto silica-based solid-core particles, in order to impart improved high pH stability. This presentation summarizes our research effort while evaluating the high pH stability of a few commercially available columns containing hybrid-coated solid-core particles.

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