Leverage the full potential of Pharmacopeia regulated U/HPLC method adaptation to increase lab effectiveness


By viewing this presentation you will:

  • Learn about the principles and importance of U/HPLC method adaptation in pharmaceutical analysis and how improved methods can help to boost laboratory effectiveness and efficiency
  • Gain insights into the significance of adhering to Pharmacopeia regulations for ensuring reliable and accurate analytical results
  • Understand various strategies and techniques for adapting U/HPLC methods, such as modifying mobile phase composition, and adjusting column parameters
  • Leverage the full potential of U/HPLC method adaptation leading to improved productivity and cost reduction in the laboratory

Event overview

In modern pharmaceutical analysis, the utilization of Pharmacopeia regulated U/HPLC (ultra/high-performance liquid chromatography) methods has become a fundamental aspect of laboratory operations.

This presentation aims to explore the diverse strategies and techniques that can be employed to fully leverage the potential of U/HPLC method adaptation, thereby enhancing the effectiveness and efficiency of laboratory processes. The presentation delves into the principles of U/HPLC and highlights the significance of adhering to Pharmacopeia regulations for ensuring reliable and accurate analytical results. Furthermore, various approaches for method adaptation, such as modification of mobile phase composition, adjustment of column parameters, and optimization of detection conditions are discussed, including the benefits and challenges associated with each adaptation strategy and insights into the factors influencing method transfer and development.

Additionally, the potential applications of U/HPLC method adaptation in pharmaceutical quality control, impurity profiling, and stability testing are explored. By understanding the nuances and intricacies of U/HPLC method adaptation, laboratories can unlock new avenues for improving productivity, reducing costs, and enhancing the overall quality of pharmaceutical analysis.

Who should view it
Lab managers and technicians working with HPLC/UHPLC methods (R&D, QC and method transfer).

What you need to know:

Format: On-demand

Duration: Approximately 60 minutes


Petra_100Petra Lewits
Global Product Manager for Analytical Chromatography, HPLC columns, Merck KGaA, Darmstadt, Germany
Petra Lewits has worked with chromatography for 40 years. In 1986 she joined the pharmaceutical R&D and QC department (Merck KGaA, Darmstadt, Germany) where she developed HPLC methods for R&D and QC of pharmaceutical APIs and formulations as well as for diet convenience foods. Since 2002 she has been a Global Product Manager for Analytical Chromatography (HPLC). In 2014 she began focusing on thin-layer chromatography (TLC). Since April 2018 Petra has had global responsibility for analytical HPLC columns.

Machtejevas_80Egidijus Machtejevas
Senior Technical Advisor, Analytical Chromatography Workflows, Merck KGaA, Darmstadt, Germany
Egidijus Machtejevas joined the R&D Department at Merck KGaA, Darmstadt, Germany in 2008. A year later he became marketing manager for North America, and in 2010–2018 Product Manager for chromatography. Currently he is a Senior Technical Advisor in the Analytical Chromatography Workflows group. Egidijus has twenty-five scientific papers and thirteen book chapters to his name, and his major focus areas include chromatography, multidimensional liquid chromatography, proteomics and mass spectrometry.






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